Shang j, yan l, du l, liang l, zhou q, liang t, bai l, tang h. Initially temozolomide was approved for the treatment of recurrent highgrade glioma at a dose of 150200 mgm 2 day for 5 days every 28day cycle i. Fever in the returning traveler is a common clinical scenario that often leads to hospitalization and may be the only symptom of a serious or lifethreatening illness. Fuo refers to a prolonged febrile illness without an established etiology despite intensive evaluation and diagnostic testing. Also, fuo in older patients and tuberculosis as a cause of. Rnai reveals proteins for metabolism and protein processing associated with langat virus infection. Chronic kidney disease of unknown origin, which is. She was in a stable state of health until eight weeks earlier, when she began to experience. Fever of unknown origin the american journal of the medical. The cytotoxic activity of temozolomide and other alkylating agents is believed to manifest largely by the formation of o 6methylguanine dna adducts. Fevers of unknown origin remain one of the most difficult diagnostic challenges in medicine. Among the ancients, typhoid fever and malaria were common causes of prolonged fevers.
Presentation of case a 70yearold woman was admitted to the hospital because of fever of unknown origin. Progressionfree survival as a surrogate endpoint for. Attitudes towards fever amongst uk paediatric intensive care staff. Sustained, unexplained fever despite a comprehensive work up is recognized as fever of unknown origin fuo, which frequently poses a clinical challenge.
Cancer of unknown primary site is a heterogeneous group of cancers for which the anatomical site of origin remains occult after detailed investigations. P etersdorf and beesons classic articles cataloguing the causes of fever of unknown origin fuo have framed the way generations of physicians think about fevers whose source is not readily explainable. This definition is now somewhat obsolete, given trends toward outpatient evaluations and more sophisticated diagnostic techniques. The patient had been in good health until two and a half weeks befo. The four recognized primary acidbase disorders comprise two metabolic. Fever of unknown origin or fever of too many origins. Yield of bone marrow examination in diagnosing the source of fever of unknown origin. The value of 18ffdgpetct in identifying the cause of fever of unknown origin fuo and inflammation of unknown origin iuo. Because fever of unknown origin may be caused by over 200 malignantneoplastic, infectious, rheumaticinflammatory, and miscellaneous disorders, clinicians often order noncluebased imaging and specific testing early in the fever of unknown origin work.
New alternative temozolomide regimens for the treatment of. Neoadjuvant chemotherapy or primary surgery in stage. Approach to the adult patient with fever of unknown origin. A new era of climate medicine new england journal of. New alternative temozolomide regimens for the treatment. Presentation of case a fiftynineyearold furnitureshop worker was admitted to the hospital because of fever of unknown origin. Recent trends in the distribution of causative diseases of fever of unknown origin. Fortunately, in most cases, fever is selflimiting or the etiology of fever is promptly established. Consequently, the primary mechanism of resistance to temozolomide is a function of. Although the traditional causes of fever of unknown origin fuo are increasingly rare, fuos are not. Weighted linear regression analysis through the origin of the plot was used to evaluate correlation between the following pairs of endpoints. Fever of unknown origin fuo was defined in 1961 as febrile illness in adults of at least 3 weeks duration, with no established diagnosis after a week of hospital investigation. One barrier to successful treatment of malignant glioma is resistance to alkylating agents such as temozolomide.
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